Supplement Sunday: CoenzymeQ10

CoQ10: More than just Heart Health

Composition with food that contains Coenzyme Q10.

This article was written by Chancellor Faloon from Life Extension Magazine (the science of a healthier life).

I’ve been taking Life Extension Supplements which unfortunately are not available in Canada (although you can order them online) for over a year now and have had no issues whatsoever with asthma or otherwise.  The quality is top-notch and I’ve added CoQ10 to my repertoire of necessary supplements.  Their magazine offers so many interesting articles…so I thought it best to share a few from the experts – starting with CoQ10.  References are included at bottom of page.

While CoQ10 is best known for promoting heart health, research is continually showing a diverse range of body-wide applications.

  • CoQ10 Improves Metabolic Syndrome

    A meta-analysis was done of trials that tested coenzyme Q10 (CoQ10) on patients with metabolic syndrome. Compared to a a placebo, CoQ10 supplementation lowered inflammation markers and increased levels of a cell-signaling protein related to improved regulation of glucose and fatty-acid breakdown.1

  • CoQ10 Increases Blood Flow

    In a clinical trial, CoQ10 (ubiquinol) improved cardiovascular function, as shown by increased flow-mediated dilation2 (widening of an artery when blood flow increases) and levels of nitric oxide (which aids in dilation). Harmful LDL oxidation was reduced with a higher dose.3

  • CoQ10 Enhances Exercise Performance

    Exercise performance and several biomarkers related to fatigue were improved in mice and humans given CoQ10 (ubiquinol). Liver and muscle glycogen content increased, providing the body with more fuel for prolonged exercise.4-6

  • CoQ10 Increases Cellular Energy

    In a cell study, CoQ10 (ubiquinol) was able to prevent age-induced oxidative stress, increase the formation of new *mitochondria (the cells’ energy generators), and was associated with the removal of old, damaged *mitochondria.7

  • CoQ10 Protects Aging Heart Muscle

    A recent review shows supporting evidence that CoQ10 can benefit heart failure patients by preventing age-related reductions in myocardial (heart muscle) ATP, the powerhouse of our cells.8

  • CoQ10 Mediates Inflammation

    To see if CoQ10 could prevent damage that may occur with strenuous exercise, 100 firemen were randomized to receive CoQ10 (ubiquinol) or a placebo. The CoQ10 group had significantly improved hematological (blood) parameters, increases in beneficial growth factors and anti-inflammatory cytokines, and a decrease in pro-inflammatory cytokines.9

  • CoQ10 Protects Against Acetaminophen Liver Injury

    A study in mice found that CoQ10 protected against acetaminophen– (Tylenol®) induced liver injury. CoQ10 also enhanced removal of damaged *mitochondria.10

*Mitochondria (in the most simple terms I was able to find) are known as the powerhouses of the cell. They are **organelles that act like a digestive system which takes in nutrients, breaks them down, and creates energy rich molecules for the cell. The biochemical processes of the cell are known as cellular respiration.

An** organelle is a subcellular structure that has one or more specific jobs to perform in the cell, much like an organ does in the body.

If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.

References

  1. Dludla PV, Orlando P, Silvestri S, et al. Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials. Int J Mol Sci. 2020 May 4;21(9).
  2. Kelm M. Flow-mediated dilatation in human circulation: diagnostic and therapeutic aspects. Am J Physiol Heart Circ Physiol. 2002 Jan;282(1):H1-5.
  3. Sabbatinelli J, Orlando P, Galeazzi R, et al. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial. Nutrients. 2020 Apr 15;12(4).
  4. Chen HC, Huang CC, Lin TJ, et al. Ubiquinol Supplementation Alters Exercise Induced Fatigue by Increasing Lipid Utilization in Mice. Nutrients. 2019 Oct 23;11(11).
  5. Cooke M, Iosia M, Buford T, et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008 Mar 4;5:8.
  6. Orlando P, Silvestri S, Galeazzi R, et al. Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes. Redox Rep. 2018 Dec;23(1):136-45.
  7. Niu YJ, Zhou W, Nie ZW, et al. Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs. Aging (Albany NY). 2020 Jan 20;12(2):1256-71.
  8. Di Lorenzo A, Iannuzzo G, Parlato A, et al. Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement. J Clin Med. 2020 Apr 27;9(5):1266.
  9. Diaz-Castro J, Moreno-Fernandez J, Chirosa I, et al. Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise. Nutrients. 2020 Feb 6;12(2).
  10. Zhang P, Chen S, Tang H, et al. CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy. Toxicol Appl Pharmacol. 2021 Jan 1;410:115355.

Sunday Supplement: Learning about Lactoferrin

Antivirals and nutritional supplements have been proposed as potentially useful against severe acute respiratory syndromes that cause Covid-19, yet you never hear any public health official mention anything about them.  Not even Vitamin D.  I wonder why?

It was brought to my attention that taking Lactoferrin capsules might be another great immune boosting factor and preventative to getting covid.

Not just any MILK

Like I said before, my general health is very good and I eat well.  However since I first heard about Covid I’ve decided to add a few more proactive supplements to my vitamin regime. Only those that I cannot get sufficient amounts from food alone. Because a healthy immune system is the best defense for fighting a virus. 

Once covid is under control in the general population and over time, I’ll go back to my vitamin basics. I’m fully aware that vitamins alone do not a healthy body make.  However, after doing some research myself, it appears that these extras cannot hurt and at the very best can help improve immunity.  So far, so good.

Lactoferrin’s Anti-Viral effects

Lactoferrin is considered an essential in providing an increased defense for our immune systems. Lactoferrin deprives unwanted bacteria in the body from the nutrients they need to continue spreading. Lactoferrin is able to boost your body with beneficial antioxidants, enhance oxygenation of the tissues and improve white blood cell health. It seems to protect against bacterial infection, possibly by preventing the growth of bacteria by depriving them of essential nutrients or by killing bacteria by destroying their cell walls.

There are many new products on the market promoting their inclusion of lactoferrin as a healthy ingredient, but what exactly is lactoferrin? Lactoferrin is a protein found naturally in cow and human milk, and it is especially abundant in colostrum. It is also found naturally in our tears and saliva, and possesses a wide variety of healthy benefits for our bodies. 

As an iron-binding milk glycoprotein, it promotes the growth of selected probiotic strains. It acts as an antimicrobial agent largely by binding the iron needed for growth of the microorganisms. 

Lactoferrin has been found to both directly and indirectly inhibit several viruses that cause disease in humans. It directly inhibits viruses by binding to viral receptor sites, thus preventing the virus from infecting healthy cells.

The importance of lactoferrin in viral infections warrants a great deal of further research and use by clinicians. There is little doubt that lactoferrin is a key molecule for the body and the immune system in the fight against viruses and other microbes, and could be an effective supplement for people with viral infections.

Maybe most promising and interesting, there is research that points to lactoferrin being able to improve the efficiency of antibiotic treatments in the fight against pathogenic microbes. Considering the out of control use of antibiotics and the rise in antibiotic resistant strains of “bad bugs,” this is very good news. Would the combination of lactoferrin and antibiotics be the knockout punch to certain bacteria that are not being killed by antibiotic treatments alone? More research is needed, but the evidence is very compelling.

Conclusion

There is little doubt that lactoferrin is a major find and a potential breakthrough as a natural nontoxic treatment in an array of human ailments. Though a handful of companies are able to produce lactoferrin at this time, there is only one company producing the apolactoferrin (iron depleted) form in large quantity. Studies suggest that the superior form to supplement with is apolactoferrin.

Disclaimer

As with everything else, take time to do your own research as there can be pros and cons to taking too much or too little of any one supplement.  The ones I’ve mentioned are supposed to help strengthen your immune system to oncoming viruses.  Having said that, depending on your overall health and what medications you may already be taking, it’s always best to check with your health provider.

This is the last of a series of natural Covid Combatants.  I’ll continue to post about other “healthy habits” in the upcoming weeks ahead.  

Sources:

Chang, R. (2020) Re: Lactoferrin and COVID-19https://pubmed.ncbi.nlm.nih.gov/32738305/

Life Extension Magazine

Symbiotics.com

Word of Mouth from a few knowledgeable individuals